WebThioredoxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest. ... To further investigate the cellular response mechanisms of these favorable outcomes, we analyzed the cell-cycle profiles, mRNA expression patterns, and ... WebMay 10, 2024 · Thioredoxin (Trx), Trx reductase, Txnip and NADPH together comprise the Trx system. Here the authors make a T cell-specific thioredoxin reductase-1 knockout …
Dissection of a redox relay: H2O2-dependent activation of the ... - PubMed
Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at … See more They are found in nearly all known organisms and are essential for life in mammals. See more Thioredoxin is a 12-kD oxidoreductase protein. Thioredoxin proteins also have a characteristic tertiary structure termed the thioredoxin fold. … See more Thioredoxin has been shown to interact with: • ASK1, • Collagen, type I, alpha 1, See more Thioredoxin is used in skin care products as an antioxidant in conjunction with glutaredoxin and glutathione. See more The primary function of Thioredoxin (Trx) is the reduction of oxidized cysteine residues and the cleavage of disulfide bonds. Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, … See more Trx1 has been shown to downregulate cardiac hypertrophy, the thickening of the walls of the lower heart chambers, by interactions with several different targets. Trx1 upregulates the … See more • RuBisCO - enzyme activity regulated by thioredoxin • Peroxiredoxin - enzyme activity regulated by thioredoxin • Thioredoxin fold • Thioredoxin reductase See more WebMar 21, 2024 · TXN (Thioredoxin) is a Protein Coding gene. Diseases associated with TXN include Retinal Ischemia and Myocarditis . Among its related pathways are Inflammasomes and Gene expression (Transcription) . Gene Ontology (GO) annotations related to this gene include RNA binding and oxidoreductase activity, acting on a sulfur group of donors, … power app tab control
Thioredoxin Expression in Primary T-Cell Acute Lymphoblastic …
WebOct 1, 2024 · Thioredoxin interacting protein (TXNIP) is a novel tumor suppressor that is down‐regulated in several cancer tissues and tumor cell lines. Overexpression of TXNIP causes cell cycle arrest at the G1/S checkpoint in the … WebIn addition, the cell cycle was altered by the activation of p53, and the complexes produce apoptosis through mitochondrial depolarization and the consequent activation of caspase-3. ... The cell solution was incubated in shake motion for 5 min at 37 °C. After incubation time, procedure in Thioredoxin Reductase Assay Kit (Sigma-Aldrich CS0170 ... WebMay 11, 2024 · G1 cell cycle arrest by upregulated TXNIP in d-allose-treated hepatocellular carcinoma may attribute to the stabilization of cell cycle inhibitor p27 (kip1) ... Yoshikawa H, Taketani Y, Tsuruo T (1996) Increased expression of thioredoxin/adult T-cell leukemia-derived factor in cisplatin-resistant human cancer cell lines. Clin Cancer Res 2(2 ... tower of babel arches national park utah