Thioester domain
WebNov 1, 2024 · The Pf-TEP had the characteristics of A2M、A2M-N-2、A2M-comp、A2M-recep、conserved thioester domain (Wu et al., 2012). Many specific structural features were well conserved in Pf-TEP , such as the thioester motif GCGEQ, the potential N-glycosylation sites, and especially the C-terminal distinctive cysteine signature, leaving no doubt that ... WebJun 19, 2007 · Crystal Structure of Acot7 N Domain. We separately crystallized and determined the structures of N- and C-domains of Acot7 at 1.8 and 2.5 Å resolution, respectively [supporting information (SI) Table 1].The N-domain monomer features a five-stranded antiparallel β-sheet surrounding an α-helix (Fig. 1 a).There is an additional C …
Thioester domain
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WebMar 16, 2024 · The N-terminal region of the adhesin contains a class II type thioester domain (TED) that is essential for efficient conjugation, particularly in liquid medium. We … WebJun 8, 2008 · In C3b, the CUB-thioester domain pair is fairly flexible relative to the rest of the molecule, and the thioester domain interacts with MG1 through a relatively small …
WebThioester containing protein 1, often called TEP1 is a key component of the arthropod innate immune system. TEP1 was first identified as a key immunity gene in 2001 through … WebPhotorhabdus species target thioester-containing proteins and their relatives to interfere with the fine-tuning of the hosts immune system. Removing TEPs therefore reduces mortality rates although in the long-term even TEP mutants succumb to the infection. The 2 Photorhabdus species behave similar in several assays but there are also
WebJun 25, 2024 · The thioester domain contains a four amino acid motif–CGEQ–that forms a β-cysteinyl-γ-glutamyl thioester bond. The reactive thioester bond, a feature of the TEP … WebMar 8, 2024 · Two classes of thioester domains (TEDs) have been predicted based on sequence with, to date, only representatives of Class I structurally characterized. Here, we …
Webcl26778: TED Superfamily. Thioester domain. This domain is found near the N-terminus of a variety of bacterial surface proteins and pili. This domain contains an unusual covalent ester bond between a conserved cysteine and glutamine residue. Links.
WebJun 24, 2024 · Open conformations of the Cys domain are associated with adenylation and thioester transfer to E2s, while a closed conformation is associated with pyrophosphate … glencove wardWebSep 22, 2010 · 3OXU PubMed Abstract: Complement factor H (FH) attenuates C3b molecules tethered by their thioester domains to self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b proteolysis that ultimately yields a surface-attached fragment (C3d) corresponding to the thioester domain ... Macromolecules body lotion tattooWebDomain Binding and Function. The HECT domain (H omologous to the E 6-AP C arboxyl T erminus) is an approximately 40 kDa (350 amino acid) catalytic domain found at the … body lotions with glycolic acidWebJun 8, 2008 · Like C3 and TEP, C5 contains eight MG domains (MG1–MG8), a CUB domain, the C5d domain (structurally homologous to the thioester-containing TE domain in C3 and TEP), the C5a domain (also... glen cove thayer houseWebMar 8, 2024 · Two classes of thioester domains (TEDs) have been predicted based on sequence with, to date, only representatives of Class I structurally characterized. Here, we present crystal structures of three Class II TEDs from Bacillus anthracis, vancomycin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococcus faecium. bodylotion tegen cellulitisWebJul 27, 2024 · In general, TEPs have several protein domains in common, including the characteristic thioester region (TER), with the exception of complement component C5 and some insect TEPs (26, 27). The TER contains a highly conserved amino acid (AA) sequence: (N)-glycine-cysteine-glycine-glutamate-glutamine-(C) (GCGEQ). glen cove washingtonWebSep 24, 2013 · Activation of complement leads to proteolytic cleavage of the central complement component, C3. Its major fragment, C3b, acts as an opsonin and becomes covalently bound to the activating surface via a reactive thioester located in the thioester (TE) domain of nascent C3b (Fig. S1A).Proteolytic processing by factor I within the CUB … body lotions with collagen peptides