Nettetrats to self-administer heroin on an intermittent access (IntA) schedule, which results in repeated spikes in brain drug concentrations, and which potently promotes addiction-like endophenotypes with other abused drugs [4]. Next, they tested the rats for motivated responding for heroin on a progressive ratio Nettet3. jan. 2024 · Drug self-administration models of addiction typically require animals to make the same response (e.g., a lever-press or nose-poke) over and over to procure and take drugs. By their design, such procedures often produce behavior controlled by stimulus-response (S-R) habits.

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